SPO2

SPO2
The other solute having a
significant influence on the
binding of O2 to Hb is 2,3diphosphoglycerate (2,3-DPG);
raising [2,3-DPG] levels, as
occurs with altitude and in
diabetes, reduces the O2
binding to Hb, shifting the
oxyhemoglobin
(HbO2)
dissociation curve to higher
P50s, just like higher CO2,
lower
pH
and
higher
temperature do.
100
98
Nielsen et al. J Appl Physiol 93: 724–731, 2002
96
Series1
94
92
90
0
Ranjan K. Dash And James B. Bassingthwaighte, Annals of
Biomedical Engineering, Vol. 38, No. 4, April 2010
5
10
15
100
98
96
94
92
90
88
Series1
0
5
10
15
98
97
96
95
94
93
92
Series1
0
5
10
15
Oxygen Cost Of Ventilation
3500
wb-VO2
3000
VO2RM (ml/min) = 301.6
R2 = 0.975
SEE = 50.7 ml O 2/min
VO2 (mL/min)
1250
[0.007994 (V E L/min)]
VO2 (mL/min)
1500
1000
2500
Indiv. VO2LOC
2000
1500
Comp. VO2LOC
1000
750
500
500
0
3
250
4
5
6
7
8
9
10
11
12
13
14
15
16
Time (min)
0
0
25
50
75
100
125
150
175
200
the respiratory muscle work normally
expended
during maximal exercise has two
significant effects on the cardiovascular
system:
1) up to 14–16% of the CO is directed to
the respiratory muscles;
2)local reflex vasoconstriction
significantly compromises blood flow to
leg locomotor muscles.
VE-BTPS (L/min)
VO2 (mL/min)
[0.007614 x VE (L/min)]
2RM (mL/min) = 346.9
1500 VO
R2 = 0.911
SEE = 73 mL O2/min
1250
1000
750
500
250
0
0
25
50
75
100
125
150
175
200
VE-BTPS (L/min)
Marks DE, Robergs RA, Nelson J, Vella C, BellWilson J, Apkarian M. Oxygen Cost Of
Ventilation And Its Effect On The VO2 Plateau.
JEPonline 2005;8(5):1-13.
Harms, Craig A., Thomas J. Wetter,
Steven R. McClaran, David F. Pegelow,
Glenn A. Nickele, William B. Nelson,
Peter Hanson, and Jerome A. Dempsey.
Effects of respiratory muscle work on
cardiac output and its distribution
during maximal exercise. J. Appl. Physiol.
85(2): 609–618, 1998.
Sharon A. Jubrias et. al. Acidosis inhibits
oxidative phosphorylation in contracting
human skeletal muscle in vivo. J Physiol (2003),
533.2, pp. 589–599
Beltrami et. al. Conventional testing methods
produce submaximal values of maximum
oxygen consumption. Br J Sports Med
2012;46:23–29.
Нетренированная
нога
Тренированная
нога
Время до отказа, мин.
8.2 +- 0.7
10.6 +- 0.7
Лактат в крови,
ммоль/л
8.0 +- 0.9
10.7 +-0.4
Лактат в мышце,
ммоль/л сухой вес
96.5 +-14.5
59.0 +- 15.1
pH в мышце
6.69 +-0.04
6.82 +-0.05
Показатель
Juel, Carsten, Christina Klarskov, Jens
Jung Nielsen, Peter Krustrup, Magni
Mohr, and Jens Bangsbo. Effect of highintensity intermittent training on lactate
and H release from human skeletal
muscle. Am J Physiol Endocrinol Metab
286: E245–E251, 2004.