RELATIONSHIP OF METABOLIC SYNDROME AND RISK OF DEVELOPING CARDIOVASCULAR DISEASE AND DIABETES FOR POPULATION OF KAZAKHSTAN KOICHUBEKOV B., SOROKINA M., LARYUSHINA YE., TURGUNOVA L., BAKIROVA R. Karaganda State Medical University, Kazakhstan Results Goals Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. Some studies have examined the relationship between MS and psychological risk factors such as depression, anxiety, tension, current perceived stress and anger. We researched risks of cardiovascular diseases, diabetes, the prevalence of states of anxiety and depression among Central Kazakhstan’s population with MS. Methods 3683 Central Kazakhstan citizens (2829 women and 854 men) aged 18 to 65 (45±12,71 (M±SD)) were examined. 543 people were diagnosed with metabolic syndrome which accounted for 14,74% (CI: 13,61; 15,93). SCORE, FINDRISK charts were used to evaluate risks. PHQ-9 and GAD-7 scales were used to determine levels of depression and anxiety. Most important differences were determined for the prevalence of diabetes and cardiovascular disease risks. Clearly increased risk for diabetes was found for 19,7% (CI 16,34; 23,06) of people with MS, almost 80,46% (CI 77,11; 83,81) had high risk of cardiovascular disorders. Among women, diabetes risks were more pronounced, whereas for men it were cardiovascular risks FINDRISK PREVALENCE MS No MS 2% 5% 5% 1% 8% Low Mild Moderate High Very high 20% 51% 35% 50% 23% Depression states were common among people with MS - almost 25% of examined had moderate, moderately severe or severe depressions. Severe anxiety level was observed for 18,05% (CI 14,8; 21,3).. Severe anxiety was observed more frequently among women than among men (19,27% (CI 15,57; 22,97) and 12,75% (CI 6,28; 19,22) respectively). However, almost 9% of men and 5,5% of women had moderately severe and severe depressions. Depression prevalence (%) 30 25 20 15 28,4 Anxiety prevalence (%) 70 20,6 60,4 60 14,7 50 40 5,9 10 5 3 30 20,6 18 20 0 10 1 0 SCORE PHQ-9 GAD-7 Minimal Mild Conclusions The prevalence of metabolic syndrome in Central Kazakhstan is significantly lower than in Europe or the U.S. However, as is the case for other countries, high risk of development of diabetes and cardiovascular disorders are observed among people with MS. Gathered results confirm the role of anxiety and depression conditions in MS development Moderate Severe
