39 615.831:616-006-092.9 V.I. Ivanova-Radkevich, L.V. Umnova, S.V. Barkanova, E.A. Makarova, E.A. Lukyanets PHOTODYNAMIC ACTIVITY OF TETRAAZACHLORIN DERIVATIVE Federal State Unitary Enterprise "GNC "NIOPIC", Moscow ABSTRACT High photodynamic activity of aqueous micellar solutions of N-methyl-pyrrolidine[3,4-b]tetraphenyl-tetraazachlorin in 4% Cremophor EL (max 715 nm) has been demonstrated in in vivo studies on mice bearing Ehrlich tumor. Key words: photodynamic therapy, photosensitizer, Ehrlich tumor, tetraazachlorin. .. -<=, '.. , *.. " , .. $, .. ';> AB> 3 E #B #? @+ “! “+(”, $ %&$ ' '%D= ("*= ' N-"[3,4-b](B ' '" ' 4% ( EL ( 715 ) ' \ in vivo %& "! #F . / %": ("*= =, (+B, # , B. B " ("*! (P) ' ''" ' B E – (+B, +"FQ +F B+# F ' #'! "#FQ +#* # * B#* [3–6]. @" 'B"!' ' "= (* E, '"=Q +B'F ' #'! / #" # E* ' (' *, "), B#&FQ ##% \% #'! [2; 7–9]. & " P "= *= B*'% '+B'! #' '% (+B' ##*&% '!'. ="# '%D! ("*! \(('F 'D% '!' +B ='== '%! \((E Q= ' " "B, * '=B #+! 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A*= "= #B% # '= 10 % ' =D +F"=. @ B#* ("*! ' +BE' H2PyrTACPh4 ' "B 0,5; 1,0; 3,0 6,0 / '" +#*= *B 24 * ''"= +* B* "' # =D ' +F"= * "= ' "B (+B, "B% 0,5 / (. 2). @ ''" D'% H2PyrTACPh4 ' "B 6,0 / B*= " 73–85 %; B' "B% 3,0 / – 55–72 %, D "B% " 1,0 / – 54–59 %. ' & " B*= +T' #! ' %% # ''" "# (+B ' "B 1,0; 3,0 6,0 / 'F "'D"% B# B QF = -. CCUCU ?@?)L?CU H> '" B # 3, Q ' ' D"# ''" (+B '" P 24 * " 0,5 * * '%D%! +*! \((, +F"%! =D 25 "! *= (B*= ' 54–67 %). B' = "'", * " B*= +T' #! ' %% # B "' &, * ' !. 1200 V % 41 1000 800 600 400 200 0 0 5 10 15 20 25 & '* %. 2. %! ! 0$' "2C$ ")*+" )"% AB ) %)",0" H2PyrTACPh4 "0+ " 0,5 " 6,0 $&/!& 0 24 " "2*' * '%& #' +* B* "'= #! # H2PyrTACPh4 ' "B 0,5 / ( 17 %) D +% +#' "*! EE! (+B ' # *B 24 * ''"=. B +% ' '" +#*= *B 0,5 * ''"= H2PyrTACPh4 ' ! D "B (0,5 /). @#*% B#% "'% . 3. V % 1200 1000 800 600 400 200 0 0 5 10 15 20 25 & '* H2PyrTACPh4 6,0 / H2PyrTACPh4 3,0 / H2PyrTACPh4 1,0 / H2PyrTACPh4 0,5 / %. 3. %! ! 0$' "2C$ ")*+" )"% AB ) %)",0" H2PyrTACPh4 "0 0,5 $&/!& 0 0,5 24 " "2*' 3/ 7/2008 OBO ' '%D= ("*= ' +B N-"[3,4-b](B ' & "! (% # '#' ''" E=% '' "# "= ' '" ( EL ' "B 0,5–6,0 / B 0,5 24 * " '"= P (" B*= 54–85 %). ' 1. " *.., " .., ? .. <. @ P 2 278 119 (2006) // F. B+. – 2006. – 17. 2. ( .. C%! #=%! " '*% B% ("* "!'= * B#*= // # . – 1992. – . 3. – C. 63–132. 3. ';> .. '% (+B% "= ("*! // !! *! D#. – 1998. – . XLII, 5. – C. 9–16. 4. * < .@. *! * B'= ("*! : +B // >B= "E.. – 2002. – . 6, )%. 1. – C. 4–8. 5. Dougherty T.J., Gomer C.J., Henderson B.W. et. al. Review: photodynamic therapy // J. Natl. Cancer Inst. – 1998. – 90. – . 889–905. 6. Huang Z. A Review of Progress in Clinical Photodynamic Therapy // Technol. Cancer Res. Treat. – 2005. – V. 4, 3 – P. 283–93. 7. Juzeniene A., Moan J. The history of PDT in Norway. 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